Cytoplasmic Pattern Anti-neutrophil Cytoplasmic Antibody (cANCA)-positive Cutaneous Leukocytoclastic Vasculitis Induced by Propylthiouracil: A Case Report
نویسندگان
چکیده
منابع مشابه
Cutaneous leukocytoclastic vasculitis with positive anti-neutrophil cytoplasmic antibodies.
Sir, Anti-neutrophil cytoplasmic antibodies (ANCA) are useful diagnostic serological markers for systemic vasculitides. W|th indirect immuno£uorescence, two distinct patterns are seen: a coarse granular, centrally accentuated cytoplasmic staining (c-ANCA) and a perinuclear staining (p-ANCA) on ethanol¢xed neutrophil cytocentrifuge preparations (1). c-ANCA is considered highly speci¢c for Wegene...
متن کاملAntineutrophil cytoplasmic antibody-positive cutaneous leukocytoclastic vasculitis associated with propylthiouracil therapy.
A dministration of propylthiouracil therapy has been associated with a hypersensitivity syndrome that typically manifests as vasculitis. Most cases of propylthiouracil therapy– induced antineutrophil cytoplasmic antibody (ANCA) positivity react to perinuclear ANCA (p-ANCA). We describe a patient who presented with cutaneous manifestations of propylthiouracil therapy hypersensitivity vasculitis ...
متن کاملLong-term outcomes of patients with propylthiouracil-induced anti-neutrophil cytoplasmic auto-antibody-associated vasculitis.
OBJECTIVE It was well known that propylthiouracil (PTU) could induce ANCA-associated vasculitis (AAV) and clinical evident vasculitis could resolve after cessation of PTU with or without immunosuppressive therapy. However, the treatment strategy for patients with PTU-induced AAV remained inconclusive and their long-term outcomes were lacking. The aim of our study was to summarize these data. ...
متن کاملPropylthiouracil-induced anti-neutrophil cytoplasmic antibodies (ANCA) skin vasculitis: the first case reported in Croatia.
Drug-induced vasculitis is a known side effect of prolonged treatment with several drugs. It is characterized by inflammation and cellular infiltration of small vessels and presence of anti-neutrophil cytoplasmic antibodies (ANCA). Propylthiouracil and hydralazine (anti-thyroid and antihypertensive drugs) are the drugs most commonly associated with drug-induced vasculitis. Small vessels of the ...
متن کاملAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis: where to go?
Enormous progress has been made during the last 25 years in our understanding of the aetiopathogenesis of the anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV). This has led to improvements in early diagnosis, treatment and secondary prevention of these diseases. Nevertheless, there are still unmet needs in the AAV. With respect to diagnosis and follow-up, sensitive ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Medicine Science | International Medical Journal
سال: 2016
ISSN: 2147-0634
DOI: 10.5455/medscience.2015.04.8323